Bile acid derivatives, processes for their preparation, and use as pharmaceuticals

Abstract From the Canadian patent

Bile acid derivatives of the formula I W - X - G, in which G ie a bile acid radical W is an active com-, pound moiety of a medicament and X is a bonding member between a bile acid radical and active compound moiety are outstandingly suitable for introducing active compounds into the enterohepatic circulation. The compounds I are absorbed and pass into the bloodstream. It is possible in this way, using the natural reabsorption of the bile acids, to achieve improved absorption of nonabsorbable or poorly absorbable pharmaceuticals. W may be for example, a peptide, an antibiotic, an antiviral substance, an anticancer agent a hepatoprotec-, tive agent, an antihyperlipidemic a diuretic, a …