Cycloalkylene azoles, processes for their production and use, and pharmaceutical preparations obtained therefrom

Abstract From the Canadian patent

The disclosure relates to cycloalkylene azoles of general Formula I, (I), wherein, is a carbocyclic or carbopolycyclic group optionally carrying at least one alkyl substituent, X is the grouping , an oxygen or sulfur atom and, Y and Z, independently of each other are , or a, nitrogen atom, as well as their pharmaceutically compatible addition salts with acids as well as processes for production thereof. The compounds possess strongly aromataseinhibiting activity and are uitable for the preparation of medicinal agents. Methods for treating estrogen induced or stimulated tumors, male infertility, and impending cardiac infarction with these compounds are also provided as well as methods for …