Substituted aromatic sulfonamides as antiglaucoma agents

Abstract From the Canadian patent

Carbonic anhydrase inhibitors of the thieno- 2,3-bthiopyran-2-sulfonamide type with a substitutedalkyl-amino group in the 4-position are topically effective in lowering intraocular pressure; the inhibitors are compounds of formula (I): wherein:, X is -S-, or -0-;, m is 0, 1 or 2 n is 0, 1 or 2, R is hydrogen or R1, R1 is 1) C2-7-alkene 2) C2-7-alkyne, 3) C1-5 alkyl having 1 2 or 3 substituents, wherein the substituents are independently:, a) halogen;, b) hydroxy; c) -NR6R7 wherein R6 and R7 are, independently: i) hydrogen, ii) C1-3 alkyl, iii) -CO-C1-3 alkyl or, iv) R6 and R7 taken together with the nitrogen to which they are, attached represent a saturated heterocycle of 5-7 members which, …