Expression and secretion of mature human beta interleukin-1 in bacillus subtilis and means and methods for its achievement
CA 2021406 A1 · Owner: Galli, Giuliano · Inventors: Lucchese, Giuseppe; Galli, Giuliano; Grandi, Guido
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
A new plasmid vector is described which can replicate in B.subtilis and which can express and secrete in the, culture medium, human beta interleukin-1 (beta IL-1) without amino acid sequences extraneous to the natural molecule, a strain of B.subtilis transformed by the vector and a method for the expression and secretion of mature human beta interleukin-l. The human beta interleukin-l thus obtained shows a specific acitvity of 1 x 109 U/mg of protein and is particularly suitable as a stimulant for the immune system, as an adjuvant in vaccines for the activation of the repair mechanism in cases of tissue damage, and for the treatment of auto-immune diseases in man.
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed July 18, 1990. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended July 18, 2010.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by July 18, 2012.
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Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.