Cyclic amidinylthiocarbapenem derivatives

Abstract From the Canadian patent

A compound represented by formula (I): (I), wherein R1 represents a hydrogen atom or a methyl group; R2 and R3, which may be the same or different each represents, a hydrogen atom or a lower alkyl group; and R4 represents a carboxyl group, a lower alkoxycarbonyl group a carbamoyl, group, a lower alkylcarbamoyl group a di-lower, alkylcarbamoyl group, or a carbonyl group substituted with a heterocyclic group selected from the group consisting of an aziridinyl group, an azetidinyl group a pyrrolidinyl, group, a piperidino group a morpholino group, a thio-, morpholino group a piperazinyl group, and a 4-lower alkyl- 1-piperazinyl group, or a pharmaceutically acceptable salt or ester thereof. The …