Antiherpes peptide derivatives having a 1,4-dioxo c n-terminus

Abstract From the Canadian patent

Disclosed herein are peptide derivatives of the formula R1NH-CO-Q-C(O)-NR2-CHCH2C(O)-Y-C(O)-NH-CHCR3(R4)-COOH- C(W)-NH-CHR5-Z wherein R1 is an optionally substituted alkyl or optionally substituted phenylalkyl, R2 is hydrogen or alkyl R3 and R4, each independently is hydrogen or alkyl or R3 and R4 are joined to, form a cycloalkyl R5 is alkyl, cycloalkyl or (cycloalkyl)alkyl Q is, a divalent radical, for example, -CH2CH2- -CH=CH- or , 1,2-cyclohexanediyl, which serves as a two carbon spacer W is oxo or, thioxo, Y is, for example an alkoxy or a monosubstituted or, disubstituted amino and Z is a terminal unit, for example, hydrogen COOH or CH2OH. The derivatives are useful for treating herpes …