Method for producing ibuprofen
CA 2017425 C · Owner: Basf Corporation · Inventors: Moss, Gary L.; Smith, Brad L.; Elango, Varadaraj
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
A method is provided for the preparation of ibuprofen by carbonylating 1-(4'-isobutylphenyl)ethanol (IBPE) with carbon monoxide in an acidic aqueous medium e.g. containing at, least 10% of water based on the weight of IBPE initially added at a terperature of at least about 10°C and a carbon monoxide pressure of at least about 500 psig, and in the presence of (1) a catalyst complex consisting essentially of a palladium compound in which the palladium has a valence of zero to 2 and is complexed with at least one monodentate phosphine ligand miscible with the organic phase of the reaction medium the, phosphorus/palladium mole ratio in said palladium compound and liqand being at least about 2.1 …
Read the whole patent
Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed May 24, 1990 and granted June 15, 1999. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended May 24, 2010.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by May 24, 2012.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.