N-(aryloxyalkyl)heteroarylpiperidines and-heteroarylpiperazines, a pro cess for their preparation and their use as medicaments

Abstract From the Canadian patent

This invention related to compounds of the formula: (see formula I), wherein, X is -p-, -S- (see formula II), or (see formula III) p is 1 or 2;, Y is hydrogen, C1 to C6 alkyl -OH, Cl, F, Hr, I, C1 to, C6 alkoxy, -CF3 -HO2, or -NH2, when p is 1;, Y is C1 to C6 alkoxy when p is 2 and X is -O-; R2 is selected from the group consisting of lower alkyl aryl lower alkyl, aryl, cycloalkyl, aroyl alkanoyl, and, phenyl sulfonyl groups; Z is -CH- or -N-;, n is 2, 3, 4, or 5; R is hydrogen, alkyl, C1 - C6-alkoxy, hydroxyl carboxyl, Cl, F, Br, I, amino, C1 - C6-mono or-dialkyl amino -NO2, lower alkyl thio, -OCF3, cyano, acylamino -CF3. trifluoroacetyl, aminocarbonyl, (see formula IV) (see formula V), …