Substituted aminoalkylphosphinic acids

Abstract From the Canadian patent

P-substituted aminoalkylphosphinic acids of the formula (see formula I), wherein R denotes an optionally fluorinated methyl group R1 denotes hydrogen, lower, alkyl, lower alkoxy hydroxy, halogen or a fluorinated methyl group and R2 and R3 denote, hydrogen or R2 denotes hydroxy lower alkoxy or halogen and R3 is hydrogen or R2 and, R3 together represent an oxo group and their pharmaceutically acceptable salts are active, as GABA B- agonists and can be used in the treatment of spinal spasticity multiple, sclerosis and cerebral palsy trigeminus neuralgia, drug withdrawal syndromes and/or, conditions of pain. They can be manufactured by methods known per se and suitable such, methods are …