Labeled chemotactic peptides to image focal sites of infection or inflammation

Abstract From the Canadian patent

The invention relates to a method of detecting a site of infection or inflammation, and a method for treating such infection or inflammation, in an individual by administering to the individual a diagnostically or therapeutically effective amount of detectably labeled, or therapeutically-conjugated chemotactic peptide which, accumulates substantially at the infected or inflamed site said, chemotactic peptide having the general structure N - X - Y - Leu - Phe - Z - W, Where: X = Formyl for agonists - A more bulky group such as t - Boc for antagonist. Y = Met or Nle. Z*= is a spacer sequence such as Gly - Gly - Gly W*= is a labeling or attachment substituent i.e. N-epsilon (DTPA) Lys - …