Separation of isomers of furo (3,4-c) pyridine derivatives

Abstract From the Canadian patent

This invention relates to a method for the separation of stereoisomers of 7-hydroxy-furo3,4-cpyridine derivatives of the formula, wherein R3, R4 and R6 represent various substituents which, comprises reacting a fully O-acetylated monosaccharide halogenide with a racemate of the selected 7-hydroxy-furo3,4-cpyridine derivative to form the (+), and (-) (O-acetylated monosaccharide) (furo3,4-c pyridine 7-yl derivative) ethers, then separating the (+) and the (-) ethers by selective crystallization in an, hydroalcoholic medium, either of the acetylated forms or of the corresponding desacetylated forms and finally, working, up each of the separated derivatives by the usual routes.