3'-tosylcytidine compounds and process for production thereof

Abstract From the Canadian patent

Novel compounds of Formula I, or, pharmaceutically acceptable salts thereof are provided:, (I), wherein Y is selected from p-toluenesulfonyl and -SO2CF3 and R2 is selected from the group comprising hydrogen trityl, methoxytrityl, dimethoxytrityl acetyl, a C2-C6, alkylacyl group, a C6-C9 arylacyl group allyl, 2,2,2-, trichloroethyl, phosphates and salts thereof tosyl and, mesyl. A process for the production of cytidine compounds, including the compounds of Formula I is, provided and comprises reacting a 2',3'-Odialkylstannylene cytidine-type compound with an amine in the presence of a sulfonyl compound. Compounds of Formula I can be used to inhibit RNA synthesis.