Method of preparing chroman derivatives, and synthesis intermediates

Abstract From the Canadian patent

entitled: Method of preparing chroman derivatives and, synthesis intermediates, in the names of: Georges GARCIA Daniel METTEFEU, Richard ROUX, Assignee: SANOFI ABSTRACT OF THE DISCLOSURE, The invention describes a method of synthesizing a compound of the formula, (I), in which - X = O or NR, - Z = an electron-attracting group - R = H, CN or NO2, - R1 + Rz + N-C=X = a 5-membered or 6-membered heterocycle, and, - R3 = H, R4 = OH or R3 + R4 = a bond said method involving intermediates of the formula (IX), in which R5 = H, Br or N(R1)CXR2. This method of synthesis does not involve the epoxide derivative of the chroman. The novel compounds of formula (IX) form a further subject of the invention.