Preparation of 2-amino-4-fluoropyrimidine derivatives
CA 2005596 C · Owner: Basf Aktiengesellschaft · Inventors: Hamprecht, Gerhard
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
A process for the preparation of 2-amino-4-fluoropyrimidine derivatives of the general formula I, (see fig. I), (R1 hydrogen alkyl, alkenyl, alkynyl, cycloalkyl, phenyl or benzyl, it being possible for the aromatic rings to be substituted, and R2 one of the R1 radicals with the exception of hydrogen) by reaction of 2,4 6-trifluoropyrimidine in an aprotic polar organic solvent with an amine of the formula III to give the 2-aminodifluoropyrimidine derivative IVa mixed with the 4-aminodifluoropyrimidine derivative IVb separation of IVa out of the, resulting reaction mixture and subsequent reaction of IVa with an alcohol in the presence of a base at from 0 to 180°C to give the …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed December 14, 1989 and granted February 17, 1998. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended December 14, 2009.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by December 14, 2011.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.