Carbapenem derivatives

Abstract From the Canadian patent

Carbapenem derivatives of formula (I): (see fig. I), wherein (a) R1 is a hydrogen atom an alkyl group of, from 1 to 6 carbon atomsr a hydroxy-lower alkyl group or a protected hydroxy-lower alkyl group of from 1 to 6 carbon atoms in its alkyl moiety, (b) COOR2 is a carboxyl group, a carboxylate anion or a protected carboxyl group, (c) R3 is an alkyl group of from 1 to 6 carbon atoms and (d) R4 is a substituted or unsubstituted heterobicyclic group of formula (II):, (see fig. II) in which the partial structure, (see fig. III) is a 5- or 6-membered, saturated or unsaturated nitrogen-containing heterocycle containing 1 to 4 hetero atoms each selected from the group consisting of oxygen sulfur …