Tumour-inhibiting saccharide conjugates

Abstract From the Canadian patent

The invention relates to a method for the preparation of glyco-conjugates of phosphorus amides with the general formula (See formula 1), where the connection of the sugar with the phosphorus amide-lost residue, and the ifosfamide-lost residue resp. occurs, preferably in the 1-position and where R1 and R2, which can be, the same or different denote hydrogen, lower C1-C4 alkyl or C1-C6 haloalkyl and where as sugar there can be present monodi-, or polysaccharides in all existing isomeric and enantiomeric forms, wherein in a known way protected bromium sugars are conjugated with the respective phosphorus compounds and freed of, the protective residues, and to the use of said compounds as …