Quinolyloxazole-2-ones useful as proteinkinase c inhibitors

Abstract From the Canadian patent

This invention relates to novel quinolyloxazole-2-ones of the formula:, (see fig. I), wherein R and R1 are each independently selected from the group consisting of hydrogen, C1-C6 alkyl, and C1-C3 alkylphenyl wherein the phenyl ring is optionally substituted with one two or three of the substituents selected from the group consisting of fluorine, chlorine, bromine C1-C4 alkyl, and, C1-C4 alkoxy; and R2 is a 2- 3-, or 4-quinolyl group, optionally, substituted with one two or three of the substituents, selected from the group consisting of fluorine chlorine, bromine, C1-C4 alkyl, C1-C4 alkoxy nitro and trifluoromethyl, or R2 is a 5- 6-, 7-, or 8-quinolyl group;, which are useful as protein …