Thermally stable and ph stable subtilisin analogs and method for production thereof
CA 1340643 C · Owner: Stabinsky, Yitzhak · Inventors: Stabinsky, Yitzhak; Zukowski, Mark M.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
A mutated subtilisin suitable for admixture to washing compositions and exhibiting substantially improved stability over naturally occurring Bacillus serine proteases is prepared by expressing a modified gene encoding subtilisin in Bacillus subtilis. A preferred subtilisin analog product differs from wild-type Bacillus alkaline proteases by having any amino acid, and preferably serine, at position 218 in place of asparagine. The product is preferably produced in a strain of B. subtilis which is mutated to block synthesis of endogenous proteases. The method of replacing an Asn or a Gly in an Asn-Gly sequence in order to improve pH and thermal stability may be applied to other sites in …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Granted July 13, 1999. A Canadian patent filed before October 1, 1989 lasted 17 years from grant, so its term ended July 13, 2016.
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Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.