Derivatives of pyrido-benzothiazine with high anti-microbial activity

Abstract From the Canadian patent

Pyrido-benzothiazine derivatives with high anti-microbial activity having the following general formula: wherein R is H or CH3; n is 0 or 1 or 2 and Y is Cl or F, wherein R1 is a C1-C6 alkyl or a C2-C6 alkenyl, or a phenyl lower alkyl, phenyl lower alkylcarbonyl lower alkylcarbonyl or lower alkyloxycarbonyl which may be , substituted with halogen or hydroxy groups and their pharmaceutically acceptable salts with acids and bases. The present invention relates also to the processes for obtaining the compounds having the general formula (I). Such processes consist in synthesis routes using as starting products 3-chloro-4-fluoroaniline, or 2,3,4-trifluoroonitrobenzene.