1, 2, 3-triazole and tetrazole substituted piperidine or tetrahydropyridine compounds useful as acetylcholine agonists

Abstract From the Canadian patent

The present invention relates to novel compounds of the following formula where the dotted line designates an optional bond: (see fig. I), wherein "het" designates a five membered heterocyclic ring which may include 1 or 2 double bonds and 1-4 heteroatoms selected from nitrogen oxygen or sulphur,provided that "het" may not designate an oxadiazole; R1 is selected from hydrogen, lower alkyl optionally substituted with phenyl, which may be substituted with halogen lower alkyl, or lower alkoxy, or a group R6-CO-NH-CH2- or R6-O-CO-, wherein R6 is lower alkyl branched or, unbranched, or phenyl optionally substituted with halogen trifluoromethyl, lower, alkyl, hydroxy lower alkoxy, or lower …