(1r,5s,6s)-2-substituted thio-6-¬(r)-1-hydroxy-ethyl -1-methyl-carbapenem-3-carboxylic acid derivatives

Abstract From the Canadian patent

Novel carbapenem compounds (1R,5S,6S)-2-substituted thio-6-(R)-1-hydroxyethyl-1-methyl-carbapenem-3-carboxylic acid derivatives are disclosed. These carbapenem compounds are represented by the following formula:, (see fig. I) and have a beta-coordinated methyl group introduced into the 1-position and a 4-pyrazolizinylthio group or a 6,7-dihydro-5Hpyrazolo1,2-a1,2,4triazolium-6-ylthio group introduced into the 2-position. In the formula, R1 represents a radical of the formula:, (see fig. II) or (see fig. III) and R2 is a hydrogen atom or an anion charge. They have antibacterial activity, and are used for prevention and treatment of bacterial infections as antibacterial agents. A process for …