Aryl-and heteroaryl piperazinyl carboxamides having central nervous system activity

Abstract From the Canadian patent

There are disclosed compounds of the formula (I) (see fig. I), wherein R1 is 1-adamantyl 3-methyl-1-adamantyl, 3-noradamantyl, unsubstituted or substituted-2-indolyl 3-indolyl, 2-benzofuranyl and 3-benzofuranyl wherein the substituents are selected from lower alkyl lower alkoxy, and halo; R2 is unsubstituted or substituted phenyl benzyl, pyridinyl, pyrinidinyl or pyrazinyl wherein the, substituents are selected from lower alkyl lower alkoxy, trifluoromethyl ,and halo; R3 is H or lower alkyl of 1 to 3 carbon atoms; n is the integer 0 or 1; m is the integer from 2 to 5; and the pharmaceutically acceptable salts thereof. Compounds according the present invention have demonstrated usefulness as …