Cloning and sequencing of the major outer capsid gylcoprotein gene of a human rotavirus

Abstract From the Canadian patent

This invention provides a human rotavirus gene and a cloned human rotavirus gene and the dsRNA gene segment coding for the major outer capsid glycoprotein of a human rotavirus. The human rotavirus may be Hu/Australia/5/77 (serotype 2), a DNA copy or a clone thereof or a vector or, a host cell containing the same or peptide sequences obtained therefrom. This may encompass vectors such as plasmids obtained therefrom or host cells that, contain them. From specific portions of cloned genes provided by the invention, comprising amino acid sequences anti-sera and anti-bodies may be, prepared primarily intended to counter infantile gastroenteritis.