Chemical probes for left-handed dna and chiral metal complexes as z-specific anti-tumor agents
CA 1339306 C · Owner: Barton, Jacqueline K. · Inventors: Barton, Jacqueline K.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
This invention concerns a coordination complex and salts and optically resolved enantiomers thereof of, the formula (R)3---M, wherein R comprises 1,10-phenanthroline or a substituted derivative thereof M, comprises a suitable transition metal e.g. ruthenium, (II) or cobalt(III), and R is bonded to M by a coordination bond. The complexes of this invention are useful in methods for labeling, nicking and cleaving DNA. The lambda enantiomer of complexes of this invention is useful in methods for specifically labeling, detecting nicking, and cleaving Z-DNA. The complexes may also be used in a method for killing tumor cells and may be combined with a pharmaceutically acceptable carrier to form a …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Granted August 19, 1997. A Canadian patent filed before October 1, 1989 lasted 17 years from grant, so its term ended August 19, 2014.
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Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.