Thiophene carboxamine derivatives and their use as pharmaceuticals

Abstract From the Canadian patent

A pharmaceutical compound of the formula in which R1, R and R3 independently are hydrogen hydroxy, halo, nitro, amino, C2-5 acylamino C1-4 alkyl, -CHO, -CH2OH, -CH2OC1-4 alkyl -COOH, -COC1-3 alkyl, -CH(OH)C1-3 alkyl C1-4, alkoxy, C2-4, alkenyloxy, C1-4 alkylthio C1-4 alkylsulphinyl, C1-4 alkylsulphonyl N-substituted heterocyclyl, optionally substituted phenyl, optionally substituted phenylthio option-, ally substituted phenylsulphinyl optionally substituted, phenylsulphonyl or optionally substituted phenylsulphonamido or R1 and R together form a C3-5 slkylene bridge; provided that at least one of R and R3 is C1-4 alkoxy or C2-4 alkenyloxy; and X is (i) -(CH2)nN(R4)2 where each R4 …