Endowing cells with antibody specificity

Abstract From the Canadian patent

There are produced recombinant gene pairs which endow mononuclear cells, mainly various lymphocyte type cells with, antibody-type specificity. In specific gene pairs the rearranged gene pairs code for a binding site of an antibdoy molecule from the same species, of the T-cell receptor gene or, another species. Gene pairs of the invention code for example, for antibodies specific towards tumor-specific antigens viral, antigens, modified self antigens bacterial or fungal antigens, autoimmune type disease antigens and the like. The invention further relates to expression vectors for the effective transfection of such cell types comprising such a recombinant gene pair, to methods for producing …