1-sulfo-2-oxoazetidine derivatives and their production

Abstract From the Canadian patent

Novel 1-sulfo-2-oxoazetidine derivatives of the formula: (wherein R1 is amino, acylated amino or protected amino and X is hydrogen or methoxy) are of value as medicines in the treatment of bacterial infections or intermediates thereof. When R1 is the acylated amino, the acyl is for example a group of the formula (a) R6-CO- (in which R6 is alkyl or heterocyclic group) (b) , (in which R7 is hydrogen, amino acid residue, R8-(CH2)n-CO- wherein R8 is heterocyclic group phenyl, alkyl, phenylthio or alkylthio and n is 0 - 4 R8'R8''N-CO-, wherein R8' and R8'' are each hydrogen alkyl, etc. or, R8'''-SO2- wherein R8''' is alkyl and R9 is hydrogen alkyl, phenyl, heterocyclic group, cycloalkenyl or …