Biologically active lysine containing octapeptides

Abstract From the Canadian patent

Novel compositions of the formula, wherein A represents an L, D or DL amino-acid selected from the group consisting of Ala, Val, Phe, p-Cl-Phe Trp, Pro, Ser, Thr, Glu, Gly, Beta Ala Abu, N-Me Ala, 5-F-Trp, 5-, Br-Trp, 5-Cl-Trp their acetylated derivatives or a, pharmaceutically acceptable acid addition salt thereof; B represents an L, D or DL amino acid amide selected from the group consisting of Thr NH2, Val NH2 Pro NH2, HO-Pro NH2, Ser NH2, Tyr NH2, Trp NH2 5-F-Trp NH2, For-, Trp NH2, Ala NH2, Gly NH2 Me Ala NH2;, X represents L-Phe or L-Tyr Y represents L-Thr or L-Val;, Z is L, D or DL-5-F-Trp 5-Br-Trp, 5-Cl-Trp, 5-I-Trp, or D-Trp; and C" and C' represent L or D Cys, Abu, Asp or Lys; …