Memory enhancing-r-n-(1-azabicyclo2.2.2oct-3-yl) benzamides and thiobenzamides

Abstract From the Canadian patent

Compounds of general formula I, (I), wherein: X represents oxygen or sulphur;, each of R1 and R3 independently represents hydrogen or a C1-C4 alkyl group;, Ar represents: a phenyl ring optionally substituted by one two or three C1-C4 alkoxy groups and/or by one or two halogen atoms;, a phenyl ring of the general formula wherein R2 represents halogen, 4,5-benzo C1-, C8 alkoxy, C1-C4 alkylcarbonyl or Am wherein, Am represents amino, methylamino or dimethylamino, R4 represents C1-C8 alkyl n is 1 or 2; or, a pyrimidinyl moiety of the general formula wherein R5 is C1-C4 alkyl;, and their N-oxides and pharmaceutically acceptable salts are useful as memory- and/or learning-enhancing agents. A …