Isoquinoline derivatives, their preparation and their use

Abstract From the Canadian patent

Compounds of formula I, (I), wherein R1 is hydrogen or C1_4alkyl; R2 is hydrogen and R3 is hydrogen or C1_4alkyl, or R2 and R3 together represent an additional bond as indicated by the dotted line; R4 is hydrogen C1_4alkyl or phenyl; R5 is methoxy or ethoxy; R6 is hydrogen hydroxy, C1_4alkoxy, hydroxy-(C2_4alkoxy) or (C1_4alkoxy)- (C2_4alkoxy); R7 and R8 are each independently C1_4alkoxy or (C1_4alkoxy)-(C2_4alkoxy); and R9 is hydrogen or halogen in free form or pharmaceutically acceptable salt form have, pharmaceutical utility, in particular as bronchodilators eosinophil accumulation and/or activation inhibiting agents and in the treatment or prophylactic treatment of obstructive or …