8-substituted quinoline derivatives and their use in therapy

Abstract From the Canadian patent

Compounds of structure (I), (I), in which R1 is hydrogen C1-6alkyl, C1-6alkoxy, C1-6alkoxy-, C1-6-alkyl C3-6cycloalkyl, C3-6cycloalkylC1-6alkyl phenyl, phenylC1-6alkyl, the phenyl groups being optionally substituted; R2 is hydrogen, C1-6alkyl C1-6alkoxy, amino, C1-6-alkylthio, halogen cyano, hydroxy, carbamoyl, carboxy, C1-6alkanoyl or trifluoromethyl; m is 1 2 or 3; p is 0, to 4; R3 is hydroxyC1-6alkyl polyhydroxyC1-6alkyl, C1-6alkoxyC1-6alkyl hydroxyC1-6alkoxy, polyhydroxy-, C1-6alkoxy C1-6alkoxyC1-6alkoxy or hydroxyC1-6alkoxy- C1-6alkoxy; and R4 is hydrogen, hydroxy C1-6alkyl, or, C1-6alkoxy, processes for their preparation intermediates, useful in their preparation pharmaceutical …