4-alkyl-1,4-dihydropyridines with paf-acether-antagonist activity

Abstract From the Canadian patent

4-alkyl-1,4-dihyropyridines, with PAF-acether-antagonist activity of formula (I) wherein R is saturated C1-C4 R' is saturated, C1-C6 alkyl which may be interrupted by an oxygen atom or, 2-tetrahydrofurfuryl and R2 is saturated C1-C4 or phenyl the compound wherein R is methyl, R' is ethyl and R2 is phenyl remain excluded, are described. The compounds (I) are prepared by: (a) reaction of (II) with (III); (b) reaction of (IV) with (V); (c) reaction of (VI) with (III) and with (VII); (d) reaction of (VIII) with (V) and with (VII); or (e) reaction of (VIII) with (VI) and with (VII) in the presence of ammonia. The compounds (I) are useful due to their antagonist activity of the platelet …