Process for preparing cis-1-carba(1-dethia)cephalosporins and intermediates therefor
CA 1332059 C · Owner: President And Fellows Of Harvard College · Inventors: Evans, David Albert; Sjogren, Eric Brian
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The present invention provides 1-benzyl (or substituted benzyl)-3.beta.-4(S)-aryl-oxazolidin-2-one-3-yl- 4.beta.-(2-arylvinyl)azetidin-2-ones represented by the formula (1):, 1, wherein Ar is phenyl, C1-C4 alkylphenyl halophenyl, C1-, C4 alkoxyphenyl, naphthyl thienyl, furyl, benzothienyl, or benzofuryl; R is phenyl C1-C4 alkylphenyl, C1-C4, alkoxyphenyl or halophenyl; Y is -CH=CH-, or -CH2-CH2-; and R' is phenyl,C1-C4 alkoxyphenyl halophenyl furyl or, naphthyl. These compounds of Formula (1) are provided via cycloaddition of a 4(S)-aryloxazolidin-2-one-3ylacetyl halide and an imine formed with a benzylamine and a 3-arylacrolein, eg. cinnamaldehyde. The above azetidinones are useful chiral …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Granted September 20, 1994. A Canadian patent filed before October 1, 1989 lasted 17 years from grant, so its term ended September 20, 2011.
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Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.