Imidazo/2,1-b/benzothiazoles useful in the treatment of memory disorders and/or irritable conditions

Abstract From the Canadian patent

Disclosed are new imidazo2,1-bbenzothiazoles of formula I, (I), wherein R1 represents a group of formula II (II), in which R4 and R5 are H or alkyl and R6 is H alkyl, phenyl, halogen, alkoxycarbonyl cyano, amido or a mono- or, dialkylamido or R1 represents a group of formula III (III), in which R7 and R8 are H or alkyl; and R2 and R3 together represent a group, or , in which m is 1 to 3 and X1 and X2 are H alkyl, alkenyl, alkoxy, arylalkoxy, aryloxy halogen, nitrile or azido; or, X1 and X2 together represent methylenedioxy and acid, addition salts thereof. Processes for preparing these new compounds which possess benzodiazepine inverse agonist and/or tranquilising properties are also …