Sulfonyldecahydro-8h-isoquino-¬2,1-g ¬1,6 - naphthyridines, optical isomers thereof and related compounds

Abstract From the Canadian patent

Compounds of the formula (I): (I), in which:, X and Y are independently hydrogen hydroxy, lower, alkyl, lower alkoxy or halo or X and Y taken, together is methylenedioxy or ethylene-1,2-dioxy, and, R is lower alkyl optionally substituted phenyl, -(CH2)mOR1 or -NR1R2 wherein m is, an integer of 1 to 6 and R1 and R2 are independently hydrogen or lower alkyl, or the group -NR1R2 forms a heterocycle of, the formula: wherein A is -CH2-, -NR1- or oxygen, wherein R1 has the above meaning and the wavy lines indicate that the hydrogen atom attached thereto is in either the .alpha.- or .beta.-position; or a pharmaceutically acceptable salt thereof, are useful as selective .alpha.2-blockers.