Tetralin esters of phenols or benzoic acids having retinoid like activity

Abstract From the Canadian patent

Retinoid-like activity is exhibited by compounds of the formula, where the R groups are independently hydrogen or lower alkyl; A, is -C(O)O-, -OC(O)- -C(O)S-, or -SC(O)-; n is 0-5; and Z is H -COB, where B is -OH or a pharmaceutically acceptable salt or B is -OR1, where R1 is an ester-forming group or B is -N(R)2 where R is, hydrogen or lower alkyl or Z is -OE where E is hydrogen or an, ether-forming group or -COR2 where R2 is hydrogen lower alkyl, phenyl or lower alkyl phenyl or Z is -CHO or an acetal derivative, thereof or Z is -COR3 where R3 is -(CH2)mCH3 where m is 0-4 and the sum of n and m does not exceed 4.