Reduction of neurotoxic effects of cytotoxic agents

Abstract From the Canadian patent

Intracranial abnormal solid cellular masses particularly tumors or adjacent tissues that may contain tumor cells, are treated by administering to the abnormal area a sufficient amount of a cytotoxic drug comprising a vinca alkaloid dispersed in a stable flowable proteinaceous matrix. The matrix substantially inhibits the migration of the drug from the site of administration, so as to maintain the primary effect of the drug in the region of administration. Migration can be further inhibited by the use of physiologically acceptable materials which modify cellular properties or physiological responses to further regionalize the placement of drug at the injection site.