Process for the enantiospecific synthesis of intermediates for hexahydro-benzo¬d naphtho ¬2,1-b azepines

Abstract From the Canadian patent

Biologically active, enantiomerically substantially pure intermediates of trans-hexahydro-benzo?naphtho2,1-b azepines are prepared. The present invention involves a process for preparing compounds of the general formula 3:, wherein: R?is , ;, Each R1 is independently H or alkyl; Q is methylene, -O- or-S-;, m and n are independently variable and may each have a value of 0, 1 or 2, with the provisos that the sum of m and n is not greater than 3 that m, may not equal zero when Q is -O- or -Sand that when Q is -CH2-, m and n, cannot both be zero; X is hydrogen, halo, alkyl, alkylthio, alkylsulfinyl alkylsufonyl, hydroxy, alkoxy or trifluoromethyl; Y is hydrogen, hydroxy, alkoxy, -OC(O)NR2R3 …