Quinolinyl ether or thioether tetrazoles as agents for the treatment of hypersensitive ailments

Abstract From the Canadian patent

This invention relates to certain quinolyl ether and thioether tetrazoles and their use as valuable pharmaceutical agents for the treatment of hypersensitive ailments, particularly as lipoxygenase inhibitors and/or leukotriene antagonists possessing anti-inflammatory and antiallergic properties. The compounds of the invention are of formula where:, A is O or S;, B is -CR2R3-, O or S; a is 0-2;, b is 0-1;, c is 0-2;, d is 0-5; n is 0-2;, R is independently hydrogen alkyl, hydroxyy, alkoxy, carbalkoxy, halo nitro, haloalkyl or cyano;, R1 and R2 are independently hydrogen alkyl or aralkyl;, vicinal R2 groups together may form a carbon-carbon double-bond;, R3 is -(CH2)x-X;, where x is 0-3 and X …