Bioadhesion drug carriers for endothelial and epithelial uptake and lesional localization of therapeutic and diagnostic agents

Abstract From the Canadian patent

This application describes the preparation and in vivo testing of surface coatings and matrix materials which when applied to or caused to comprise the carriers for drugs and diagnostic agents, and administered in a fashion that allows efficient vascular access causes the, carriers to recognize determinants present on normal or focally diseased endothelium, and induces the following in vivo effects: 1) rapid, partial or total endothelial envelopment or the drug (diagnostic) carrier; 2) sequestration of the carrier and protection of the entrapped agent from blood vascular clearance at an early time (2 minutes) when the endothelial pocket which envelops the carrier still invaginates into the …