Large scale synthesis of twelve member diazamonocyclic compounds

Abstract From the Canadian patent

A process is disclosed for synthesizing large quantities of a compound of formula I, I, wherein a solution of a compound of formula II II, is mixed with a solution of a compound of formula III III, under suitable process conditions and wherein A, same or, different, is N-R O, S, CRR' or P(O)R, and R and R' are, hydrogen alkyl, alkylidene, aryl, tosyl, allyl or benzyl and, B is O. Compounds of formula I may be reduced to form an azacorand of formula IV, IV, wherein K and L same or different, are N-R, O, S, CRR' or, P(O)R, and R and R' are hydrogen, alkyl alkylidene, aryl, tosyl, allyl or benzyl. Also disclosed is a compound of formula IV synthesized in accordance with the above procedure …