Multivesicular liposomes having a biologically active substance encapsulated therein in the presence of a hydrochloride

Abstract From the Canadian patent

Multivesicular Liposomes Having a Biologically Active Substance Encapsulated Therein, In the Presence of a Hydrochloride Abstract of the Disclosure, Disclosed are large multivesicular liposomes containing biologically active substances the multivesicular, liposomes having defined size distribution adjustible average, size, adjustible internal chamber size and number and having, substantially higher encapsulation efficiency and substantially slower leakage rate of the biologically active substance than in the previous art. The process comprises dissolving a lipid component in volatile organic solvents adding an immiscible, aqueous component containing a hydrochloride and one or more …