Phenyl-substituted piperidine compounds and their preparation and use in treating calcium overload in brain cells of mammals

Abstract From the Canadian patent

Novel piperidine compounds having the formula wherein, R3 is 3,4-methylenedioxyphenyl aryl or heteroaryl which, are optionally substituted with one or more C1-6-alkyl C1-6-alkoxy, C3-8-cycloalkyl, C3-5-alkylene or aralkoxy, R1 is straight or branched C1-8-alkyl C4-8-alkoxy-C4-8-al-, kyl, C4-7-cycloalkyl aryloxy-C3-8-alkyl, C4-8-alkenyl, or, C4-8-cycloalkylalkyl or R1 may also be hydrogen or C1-3-, alkyl when R3 is aryl, which is substituted with two or more of C1-6- alkyl, C1-6-alkoxy, C3-8-cycloalkyl aralkoxy, or with C3-5- alkylene. X is hydrogen or halogen and wherein, Y is O or S, and a salt thereof with a pharmaceutically acceptable acid. The novel compounds are useful in the treatment …