Fecal occult blood test reagents and methods

Abstract From the Canadian patent

Abstract of the Disclosure, An improved method for detecting peroxidatively active materials in a sample is provided the method incorporating antimalarial drugs such as quinine, quinidine, chloroquine, primaquine and, quinacrine as modulating compounds. In a preferred embodiment, the method is a fecal occult blood test (FOBT), in which a fecal specimen is contacted with chromogen and a hydroperoxide in the presence of a selected quinoline derivative. The method enables careful modulation of test sensitivity and specificity and further provides an FOBT in which interference from dietary meat ingestion is substantially eliminated.