Intensely sweet l-aspartyl-3-(bicycloalkyl)-l-alanine alkyl esters

Abstract From the Canadian patent

The present invention relates to L-aspartyl-3- (bicycloalkyl)-L-alanine alkyl esters having high sweetness intensity, of the formula:, wherein R1 is a substituted or an unsubstituted bicycloalkyl ring, said ring having 7 to 8 carbon atoms the 2-position ring, carbon atom is bound to the alanine moiety the two carbon, atoms of the ring that are vicinal to the 2-position carbon are each substituted by a hydrogen or lower alkyl the total number, of alkyl groups bound to the vicinal carbons is less than three, and R2 is methyl. The "2R" configuration enantiomers of the R1 group are especially preferred. In preferred embodiments of the invention, R1 is a bornyl camphanyl, norbornyl, …