Avermectin derivatives

Abstract From the Canadian patent

There are disclosed novel avermectin, compounds wherein the 4" or 4' hydroxy group is oxidized to an oxo group and replaced with a semicarbazone, carbonyl- or sulfonyl- hydrazone hydrazone, or oxime, and optionally reduced to the corresponding semicarbazide, carbonyl- or sulfonylhydrazide or hydrazine. The semicarbazones and hydrazones are prepared from the 4" or 4' oxo compound using the corresponding semicarbazides or hydrazines. The compounds have utility as anti-parasitic agents and compositions for that use are also disclosed. The compounds are also highly potent insecticides against agricultural pests. Compositions for such uses are also disclosed.