3-(2-haloethyl)-1,4-oxathiins and 2-(2-haloethyl)-1, 4-dithiins and treatment of leukemia and tumors therewith

Abstract From the Canadian patent

Novel 3-(2-haloalkyl)-1,4-oxathiins or 2-(2-haloalkyl)- 1,4-dithiins, useful for regressing or inhibiting the growth of leukemia and tumors in mammals. The compounds have the formula:, wherein, R1 is an alkyl group containing up to 4 carbon atoms cyclohexyl or phenyl;, R2 is hydrogen or ethyl; R3 and R4 are each hydrogen, methyl or ethyl and, when either R3 or R4 is methyl or ethyl the other, is hydrogen;, X is halogen: and Y is oxygen or sulfur and, when Y is sulfur R3 and R4 are both hydrogen. and pharmaceutical compositions comprising said compounds in admixture with a pharmaceutically acceptable substantially non-toxic carrier.