Imidazole derivatives, process for production thereof, and use thereof

Abstract From the Canadian patent

Disclosed are imidazole derivatives represented by formula I:, I, wherein R is a hydrogen atom or wherein R2, is a hydrogen atom or a hydroxy-protecting group R2 protecting, either a single hydroxyl group or two hydroxyl groups together when R2 is a hydroxy-protecting group, and R3 is a hydrogen atom or OR2; A is CONH2 or CN; and R1 is a hydrogen atom lower alkyl, hydroxy-lower alkyl, or phenyl. Also disclosed are six processes for producing these novel compounds among which a typical process comprises reacting a starting imidazole compound having a halogen at the 5-position thereof with an acetylene derivative to alkynylate the 5-position. Furthermore, the compounds have remarkable …