Cardioprotective agent and a therapeutic agent for ischemic disease comprising n-containing heterocyclic compounds, and a process for the preparation of the same compounds

Abstract From the Canadian patent

A pharmaceutical composition as a cardioprotective agent or as a therapeutic agent for ischemic disease comprising a compound of the formula:, wherein R1 is lower alkyl substituted with a heterocyclic group; carbamoyl, substituted with heterocyclic(lower)alkyl or with lower alkylamino(lower)alkyl;, N-containing heterocycliccarbonyl optionally substituted with lower alkyl; or ureido substituted with, lower alkylamino(lower)alkyl; and R2 is phenyl substituted with nitro, and X is =N- or , in which R3 is lower alkyl; or, R2 is lower alkyl, and, X is , in which R3 is phenyl substituted with nitro;, or its salt, as an active ingredient in association with, a pharmaceutically acceptable …