Derivatives of (1-hydroxy-2-piperidylalkyl)-indol-2-ones, 2-quinolinones, 2-benzobazapinones, benzimidazol-2-ones, and quinazolin-2-ones, their preparation and their applicationin therapeutics

Abstract From the Canadian patent

38 -, ABSTRACT, "DERIVATIVES OF (1-HYDROXY-2-PIPERIDYLALKYL)-INDOL-2-ONES 2-QUINOLINONES, 2-BENZOBAZAPINONES, BENZIMIDAZOL-2-ONES AND QUINAZOLIN-2-ONES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS", A compound in the form of a pure optical isomer or a mixture thereof, of formula (I):, in which:, Z represents a group of formula -CH2- -C(CH3)2-, -CH=CH-, -(CH2)2-, -(CH2)3- -NH- or -N(CH3)CH2-, in which, the nitrogen is bonded to the carbonyl group; R1 represents hydrogen or a C1-C4 alkyl group; R2 represents hydrogen or a methyl group; and R3 represents:, a phenoxy group which is unsubstituted or substituted by a halogen or a methyl group, a naphthyloxy group a phenylmethyl group …